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Endocrine Abstracts

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ea0049oc14.3 | Thyroid Cancer | ECE2017

TERT, BRAF and NRAS in the molecular profile of metastatic thyroid cancer: differences between primary and distant disease

Melo Miguel , Gaspar da Rocha Adriana , Batista Rui , Vinagre Joao , Joao Martins Maria , Costa Gracinda , Ribeiro Cristina , Carrilho Francisco , Leite Valeriano , Lobo Claudia , Manuel Cameselle-Teijeiro Jose , Sobrinho-Simoes Manuel , Soares Paula

Context: Little is known about the frequency of key mutations in thyroid cancer metastases and its relationship with the primary tumor genotype.Objectives: To evaluate the frequency of TERT promoter (TERTp), BRAF and NRAS mutations in metastatic thyroid carcinomas, analyzing primary thyroid tumors, lymph node metastases (LNM) and distant metastases.Material and Methods: Mutation analysis was performed in 437 tissue samples from 204...
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ea0040oc4 | (1) | ESEBEC2016

TERT promoter mutations in pancreatic endocrine tumours are frequent in tumours from patients with hereditary syndromes

Vinagre Joao , Nabais Joana , Pinheiro Jorge , Batista Rui , Oliveira Rui , Goncalves Pedro , Pestana Ana , Reis Marta , Mesquita Barbara , Pinto Vasco , Lyra Joana , Godinho Miguel , Lopes Jose Manuel , Sobrinho-Simoes Manuel , Soares Paula

Objective: One of the hallmarks of cancer is its unlimited replicative potential. Recently, telomerase promoter (TERTp) mutations were presented as novel mechanism for telomerase re-activation/expression. Due to this fact, it was our objective to study pancreatic endocrine tumours (PET) and related cell lines, to determine if TERTp mutations were present.Design: We performed characterization of the TERTp in a series of 55 PETs and three common PET cell l...
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ea0035p1149 | Thyroid Cancer | ECE2014

Prognostic significance of TERT promoter mutations in follicular cell-derived thyroid carcinomas

Melo Miguel , da Rocha Adriana Gaspar , Vinagre Joao , Batista Rui , Peixoto Joana , Celestino Ricardo , Salgado Catarina , Eloy Catarina , Lima Jorge , Amaro Teresina , Lobo Claudia , Moura Margarida , Cavaco Branca , Leite Valeriano , Cameselle-Teijeiro Jose Manuel , Carrilho Francisco , Carvalheiro Manuela , Maximo Valdemar , Sobrinho-Simoes Manuel , Soares Paula

Context: Telomerase promoter mutations (TERT) were recently described in follicular cell-derived thyroid carcinomas (FCDTC) and seem to be more prevalent in aggressive cancers.Objectives: We aimed to evaluate the frequency of TERT promoter mutations in thyroid lesions and to investigate the prognostic significance of such mutations in a large cohort of patients with differentiated thyroid carcinomas (DTC).<p class="abstext"...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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